Working at the regional level poses a series of challenges for donors. DFID’s Regional Assistance Plan (RAP) in Latin America aims to influence regional policy by working with the World Bank and the Inter-American Development Bank, two of the main IFI’s in the region. Without a bilateral programme (except in Nicaragua) DFID faces organisational and contextual challenges which pose a series of fundamental questions. Their answers could potentially inform a process of regional strategy design; but also of global thinking about donors as part of a network of partners and allies with and through which they work to achieve their core objectives. This document investigates five key questions for them.