‘WISE-UP to Climate’ is a project that demonstrates natural infrastructure as a ‘nature-based solution’ for climate change adaptation and sustainable development. The project will develop knowledge on how to use portfolios of built water infrastructure (eg. dams, levees, irrigation channels) and natural infrastructure (eg. wetlands, floodplains, watersheds) for poverty reduction, water-energy-food security, biodiversity conservation, and climate resilience. WISE-UP will show the application of optimal portfolios of built and natural infrastructure using dialogue with decision-makers to agree trade-offs.